Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

Abstract Background Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an innovative pharmacological strategy via inhibiting the same activated t...

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Bibliographic Details
Main Authors: Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Späni, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Neuroinflammation
Subjects:
Cytokines
Microglia
Protein kinase inhibitors
Mitogen-activated protein kinase 14
Neuroprotective agents
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s12974-017-0845-2

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http://link.springer.com/article/10.1186/s12974-017-0845-2

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