MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation

MiR-181d-5p Targets KLF6 to Improve Ischemia/Reperfusion-Induced AKI Through Effects on Renal Function, Apoptosis, and Inflammation

Renal tubular epithelial cell (RTEC) death and renal interstitial inflammation are the most crucial pathophysiological changes in acute kidney ischemia/reperfusion injury (IRI). The microRNA (miR)-181d family plays diverse roles in cell proliferation, apoptosis and inflammation, but its renal target...

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Bibliographic Details
Main Authors: Yue Zhang, Chenyu Li, Chen Guan, Bin Zhou, Lin Wang, Chengyu Yang, Li Zhen, Jie Dai, Long Zhao, Wei Jiang, Yan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
MiR-181d-5p
KLF6
IRI
inflammation
apoptosis
renal function
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00510/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00510/full

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