Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling
Kleefstra syndrome is a neurodevelopmental disorder associated with hapoinsufficiency of the histone methyltransferase EHMT1. Here the authors show using induced pluripotent cells-derived neurons from patients that network dysfunction occurs and is due to dysfunction of the NMDA receptor.
Main Authors: | , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12947-3 |