Zinc binding groups for histone deacetylase inhibitors

Zinc binding groups for histone deacetylase inhibitors

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs. Due to the high affinity to the zinc ion, hydroxamic acid is the most commonly used ZBG in the structure of...

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Bibliographic Details
Main Authors: Lei Zhang, Jian Zhang, Qixiao Jiang, Li Zhang, Weiguo Song
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Histone deacetylase inhibitor
zinc binding group
anti-tumour
selectivity
drug design
Online Access:http://dx.doi.org/10.1080/14756366.2017.1417274

Internet

http://dx.doi.org/10.1080/14756366.2017.1417274

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