Peripheral Dopamine 2-Receptor Antagonist Reverses Hypertension in a Chronic Intermittent Hypoxia Rat Model

Peripheral Dopamine 2-Receptor Antagonist Reverses Hypertension in a Chronic Intermittent Hypoxia Rat Model

The sleep apnea-hypopnea syndrome (SAHS) involves periods of intermittent hypoxia, experimentally reproduced by exposing animal models to oscillatory PO<sub>2</sub> patterns. In both situations, chronic intermittent hypoxia (CIH) exposure produces carotid body (CB) hyperactivation genera...

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Bibliographic Details
Main Authors: Elena Olea, Inmaculada Docio, Miguel Quintero, Asunción Rocher, Ana Obeso, Ricardo Rigual, Angela Gomez-Niño
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
chronic intermittent hypoxia
carotid body
hypertension
dopamine
domperidone
peripheral dopamine antagonist
Online Access:https://www.mdpi.com/1422-0067/21/14/4893

Internet

https://www.mdpi.com/1422-0067/21/14/4893

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