An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid

An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid

Stroke is the second leading cause of death after heart disease globally and cerebral ischemic stroke accounts for approximately 70% of all incident stroke cases. We selected four main compounds from a patent Chinese medicine, Qingkailing (QKL) injection, including baicalin from Scutellaria baicalen...

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Bibliographic Details
Main Authors: Chongyang Ma, Xueqian Wang, Tian Xu, Shuang Zhang, Shuling Liu, Changming Zhai, Zisong Wang, Jie Mu, Changxiang Li, Fafeng Cheng, Qingguo Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
network pharmacology
ischemic stroke
combination of drug
Chinese medicine
protein protein-interaction (PPI) network
topological analysis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00519/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00519/full

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