Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both in vitro and in vivo. Studies have shown that the neurotoxicity of rotenone may be related to its ability to generate reactive oxygen species (ROS), leading to neuronal apo...

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Bibliographic Details
Main Authors: Kuppusamy Tamilselvam, Nady Braidy, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Nagarajan Rajendra Prasad, Subburayan Karthikeyan, Arokyasamy Justin Thenmozhi, Subash Selvaraju, Gilles J. Guillemin
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2013/102741

Internet

http://dx.doi.org/10.1155/2013/102741

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