Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

Age-related hearing loss (ARHL) is the most common sensory impairment in the elderly affecting millions of people worldwide. To shed light on the genetics of ARHL, a large cohort of 464 Italian patients has been deeply characterized at clinical and molecular level. In particular, 46 candidate genes,...

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Bibliographic Details
Main Authors: Giorgia Girotto, Anna Morgan, Navaneethakrishnan Krishnamoorthy, Massimiliano Cocca, Marco Brumat, Sissy Bassani, Martina La Bianca, Mariateresa Di Stazio, Paolo Gasparini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Genetics
Subjects:
hearing loss
new gene discovery
zebrafish model
CRISPR-Cas9
next-generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00142/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00142/full

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