Chronic Microglial Activation in the GFAP-IL6 Mouse Contributes to Age-Dependent Cerebellar Volume Loss and Impairment in Motor Function

Chronic Microglial Activation in the GFAP-IL6 Mouse Contributes to Age-Dependent Cerebellar Volume Loss and Impairment in Motor Function

Chronic microglial activation is a prominent feature of many chronic neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. To investigate the effects of chronic microglial activation on cerebellar structure and motor function throughout the lifespan, the transgenic GFAP-IL6 mous...

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Bibliographic Details
Main Authors: Erika Gyengesi, Alejandra Rangel, Faheem Ullah, Huazheng Liang, Garry Niedermayer, Rustam Asgarov, Madhuri Venigalla, Dhanushka Gunawardena, Tim Karl, Gerald Münch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
chronic microglia activation
motor function
degeneration
interleukin-6
cerebellum
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00303/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.00303/full

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