Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs

Effective screening of drugs to treat amyloid oligomeric aggregates associated with Alzheimer’s is needed for drug development. Here the authors report on the creation of an amyloid corona around a plasmonic nanoparticle to monitor amyloid degradation when exposed to potential drugs and demonstrate...

Full description

Bibliographic Details
Main Authors: Dongtak Lee, Dongsung Park, Insu Kim, Sang Won Lee, Wonseok Lee, Kyo Seon Hwang, Jeong Hoon Lee, Gyudo Lee, Dae Sung Yoon
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20611-4