Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi

Modulating the expression or function of the enigmatic MYC protein has demonstrated efficacy in an array of cancer types and a marked potential therapeutic index and safety profile. Despite its high therapeutic value, specific and selective inhibitors or downregulating therapeutics have proven diffi...

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Bibliographic Details
Main Authors: Alexandra Maria Psaras, Katarina T. Chang, Taisen Hao, Tracy A. Brooks
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
MYC
Online Access:https://www.mdpi.com/1420-3049/26/18/5542