Chemoenzymatic Synthesis of Enantiomeric, Bicyclic δ-Halo-γ-lactones with a Cyclohexane Ring, Their Biological Activity and Interaction with Biological Membranes

Chemoenzymatic Synthesis of Enantiomeric, Bicyclic δ-Halo-γ-lactones with a Cyclohexane Ring, Their Biological Activity and Interaction with Biological Membranes

Starting from 1-acetyl-1-cyclohexene, three enantiomeric pairs (ee ≥ 99%) of bicyclic δ-halo-γ-lactones with cyclohexane ring were obtained in five-step synthesis. The key stereochemical steps were lipase-catalyzed kinetic resolution of racemic 1-(cyclohex-1-en-1-yl) etha...

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Bibliographic Details
Main Authors: Marcelina Mazur, Aleksandra Włoch, Fouad Bahri, Hanna Pruchnik, Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Gabriela Maciejewska, Witold Gładkowski
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
lactones
halolactonisation
kinetic resolution ofalcohols
antimicrobial activity
antiproliferative activity
hemolytic activity
erythrocytes
biological membranes
Online Access:https://www.mdpi.com/2218-273X/10/1/95

Internet

https://www.mdpi.com/2218-273X/10/1/95

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