Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells

Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells

In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors...

Full description

Bibliographic Details
Main Authors: Sergiy V. Korol, Zhe Jin, Yang Jin, Amol K. Bhandage, Anders Tengholm, Nikhil R. Gandasi, Sebastian Barg, Daniel Espes, Per-Ola Carlsson, Derek Laver, Bryndis Birnir
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418300987

Internet

http://www.sciencedirect.com/science/article/pii/S2352396418300987

Similar Items