Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer

Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer

Abstract Background Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast cancer risk, a greater pathologic complete response to neoadjuvant therapy...

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Bibliographic Details
Main Authors: Erin D. Giles, Sonali Jindal, Elizabeth A. Wellberg, Troy Schedin, Steven M. Anderson, Ann D. Thor, Dean P. Edwards, Paul S. MacLean, Pepper Schedin
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Breast Cancer Research
Subjects:
Obesity
Macrophage
Metabolism
Adipose
Tumor microenvironment
Liver
Online Access:http://link.springer.com/article/10.1186/s13058-018-0974-2

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http://link.springer.com/article/10.1186/s13058-018-0974-2

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