Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib

Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib

The emergence of secondary resistance is the main failure cause of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) as a targeted therapy for non-small cell lung cancer (NSCLC). EGFR mutations of NSCLC cells can markedly increase glutamine transporter (SLC1A5) expression, ther...

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Bibliographic Details
Main Authors: Yaming Liu, Xianming Ge, Jinlong Pang, Yuhan Zhang, Hao Zhang, Hongyan Wu, Fangtian Fan, Hao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
almonertinib
SLC1A5
apoptosis
autophagy
EGFR-TKI
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.671328/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.671328/full

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