Rapid diagnostic tests failing to detect infections by Plasmodium falciparum encoding pfhrp2 and pfhrp3 genes in a non-endemic setting

Rapid diagnostic tests failing to detect infections by Plasmodium falciparum encoding pfhrp2 and pfhrp3 genes in a non-endemic setting

Abstract Background Rapid diagnostic tests (RDTs) detecting the histidine-rich protein 2 (PfHRP2) have a central position for the management of Plasmodium falciparum infections. Yet, variable detection of certain targeted motifs, low parasitaemia, but also deletion of pfhrp2 gene or its homologue pf...

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Bibliographic Details
Main Authors: Grégoire Pasquier, Vincent Azoury, Milène Sasso, Laëtitia Laroche, Emmanuelle Varlet-Marie, Sandrine Houzé, Laurence Lachaud, Patrick Bastien, Yvon Sterkers, Maude F. Leveque
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Malaria Journal
Subjects:
False-negative RDTs
Imported malaria
Gene deletion
Genetic diversity
LAMP
Screening
Online Access:http://link.springer.com/article/10.1186/s12936-020-03251-3

Internet

http://link.springer.com/article/10.1186/s12936-020-03251-3

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