An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities

A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a s...

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Bibliographic Details
Main Authors: Fanny Mathias, Youssef Kabri, Liliane Okdah, Carole Di Giorgio, Jean-Marc Rolain, Cédric Spitz, Maxime D. Crozet, Patrice Vanelle
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
5-nitroimidazole
Suzuki-Miyaura/Sonogashira
regioselectivity
microwave
antiparasitic
antibacterial
Online Access:https://www.mdpi.com/1420-3049/22/8/1278

Internet

https://www.mdpi.com/1420-3049/22/8/1278

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