Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Valsartan (VAL), an antagonist of angiotensin II receptor type 1, has antihypertensive and multiple cardiovascular protective effects. The pleiotropic functions of VAL are related to the increased synthesis and biological activity of intravascular nitric oxide (NO). In this study, the role and mecha...

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Bibliographic Details
Main Authors: Yingshuai Zhao, Liuyi Wang, Shanshan He, Xiaoyan Wang, Weili Shi
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2017-05-01
Series:Bosnian Journal of Basic Medical Sciences
Subjects:
Valsartan
nitric oxide
protein kinase B
adenosine monophosphate-activated protein kinase
endothelial nitric oxide synthase
Online Access:https://bjbms.org/ojs/index.php/bjbms/article/view/1319

Internet

https://bjbms.org/ojs/index.php/bjbms/article/view/1319

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