The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

Abstract Background The continued spectre of resistance to existing anti-malarials necessitates the pursuit of novel targets and mechanisms of action for drug development. One class of promising targets consists of the 80S ribosome and its associated components comprising the parasite translational...

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Bibliographic Details
Main Authors: Christine Moore Sheridan, Valentina E. Garcia, Vida Ahyong, Joseph L. DeRisi
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Malaria Journal
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12936-018-2616-7