Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK

Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK

The nonreceptor tyrosine TEC kinases are key regulators of the immune system and play a crucial role in the pathogenesis of diverse hematological malignancies. In contrast to the substantial efforts in inhibitor development for Bruton’s tyrosine kinase (BTK), specific inhibitors of the other TEC kin...

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Bibliographic Details
Main Authors: Michael Forster, Xiaojun Julia Liang, Martin Schröder, Stefan Gerstenecker, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Matthias Gehringer
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
tyrosine kinases
bone marrow tyrosine kinase on chromosome X
Bruton’s tyrosine kinase
Janus kinase 3
covalent inhibitors
chemical probes
Online Access:https://www.mdpi.com/1422-0067/21/23/9269

Internet

https://www.mdpi.com/1422-0067/21/23/9269

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