Total Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients

Total Phenytoin concentration is not well correlated with active free drug in critically-ill head trauma patients

Objective: Phenytoin is an antiepileptic drug used widely for prophylaxis and treatment of seizure after neurotrauma. Phenytoin has a complex pharmacokinetics and monitoring of its serum concentrations is recommended during treatment. Total phenytoin concentration is routinely measured for monitorin...

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Bibliographic Details
Main Authors: Kourosh Sadeghi, Farin Hadi, Arezoo Ahmadi, Hadi Hamishehkar, Mohammad-Taghi Beigmohammadi, Ata Mahmoodpoor, Mohammad Reza Rouini, Shirin Farhudi, Narjes Hendoui, Atabak Najafi, Mojtaba Mojtahedzadeh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Research in Pharmacy Practice
Subjects:
Critically-ill patients; free drug concentration; head trauma; hypoalbuminemia; Phenytoin
Online Access:http://www.jrpp.net/article.asp?issn=2319-9644;year=2013;volume=2;issue=3;spage=105;epage=109;aulast=Sadeghi

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http://www.jrpp.net/article.asp?issn=2319-9644;year=2013;volume=2;issue=3;spage=105;epage=109;aulast=Sadeghi

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