Neutrophils Compromise Retinal Pigment Epithelial Barrier Integrity

We hypothesized that neutrophils and their secreted factors mediate breakdown of the integrity of the outer blood-retina-barrier by degrading the apical tight junctions of the retinal pigment epithelium (RPE). The effect of activated neutrophils or neutrophil cell lysate on apparent permeability of...

Full description

Bibliographic Details
Main Authors: Jiehao Zhou, Shikun He, Ning Zhang, Christine Spee, Peng Zhou, Stephen J. Ryan, Ram Kannan, David R. Hinton
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/289360