In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants

In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants

In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isol...

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Main Authors: Valter F de Andrade-Neto, Adrian M Pohlit, Ana Cristina S Pinto, Ellen Cristina C Silva, Karla L Nogueira, Márcia RS Melo, Marycleuma C Henrique, Rodrigo CN Amorim, Luis Francisco R Silva, Mônica RF Costa, Rita CS Nunomura, Sergio M Nunomura, Wilson D Alecrim, M das Graças C Alecrim, F Célio M Chaves, Pedro Paulo R Vieira
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2007-06-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
neosergeolide
ellipticine
aspidocarpine
4-nerolidylcatechol
Pothomorphe peltata
Picrolemma sprucei
Aspidosperma spp
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300016

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