Characterization of Timed Changes in Hepatic Copper Concentrations, Methionine Metabolism, Gene Expression, and Global DNA Methylation in the Jackson Toxic Milk Mouse Model of Wilson Disease

Characterization of Timed Changes in Hepatic Copper Concentrations, Methionine Metabolism, Gene Expression, and Global DNA Methylation in the Jackson Toxic Milk Mouse Model of Wilson Disease

Background: Wilson disease (WD) is characterized by hepatic copper accumulation with progressive liver damage to cirrhosis. This study aimed to characterize the toxic milk mouse from The Jackson Laboratory (Bar Harbor, ME, USA) (tx-j) mouse model of WD according to changes over time in hepatic coppe...

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Bibliographic Details
Main Authors: Anh Le, Noreene M. Shibata, Samuel W. French, Kyoungmi Kim, Kusum K. Kharbanda, Mohammad S. Islam, Janine M. LaSalle, Charles H. Halsted, Carl L. Keen, Valentina Medici
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
Wilson disease
copper
DNA
methylation
gene expression
Online Access:http://www.mdpi.com/1422-0067/15/5/8004

Internet

http://www.mdpi.com/1422-0067/15/5/8004

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