3-Hydroxyolean-12-en-27-oic Acids Inhibit RANKL-Induced Osteoclastogenesis in Vitro and Inflammation-Induced Bone Loss in Vivo

3-Hydroxyolean-12-en-27-oic Acids Inhibit RANKL-Induced Osteoclastogenesis in Vitro and Inflammation-Induced Bone Loss in Vivo

Olean-12-en-27-oic acids possess a variety of pharmacological effects. However, their effects and underlying mechanisms on osteoclastogenesis remain unclear. This study aimed to investigate the anti-osteoclastogenic effects of five olean-12-en-27-oic acid derivatives including 3α,23-isopropylidenedi...

Full description

Bibliographic Details
Main Authors: Wonyoung Seo, Suhyun Lee, Phuong Thao Tran, Thi Quynh-Mai Ngo, Okwha Kim, Thanh Huong Le, Nguyen Hai Dang, Cheol Hwangbo, Byung Sun Min, Jeong-Hyung Lee
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
3-hydroxyolean-12-en-27-oic acid
osteoclastogenesis
RANKL
c-Fos
NFATc1
Online Access:https://www.mdpi.com/1422-0067/21/15/5240

Internet

https://www.mdpi.com/1422-0067/21/15/5240

Similar Items