Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

Enterochromaffin cells (EC) synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility, secretion and visceral sensation. Abnormal regulation of 5-HT occurs in gastrointestinal disorders and Inflammatory...

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Bibliographic Details
Main Authors: Andromeda Linan Rico, Fernando Ochoa-Cortes, Arthur Beyder, Suren Soghomonyan, Alix Zuleta-Alarcon, Vincenzo Coppola, Fievos Leontiou Christofi
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Neuroscience
Subjects:
Adenosine
ATP
Mechanotransduction
purinergic receptors
visceral sensation
enterochromaffin cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00564/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00564/full

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