Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics

Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics

Summary: Cardiac stimulation via sympathetic neurons can potentially trigger arrhythmias. We present approaches to study neuron-cardiomyocyte interactions involving optogenetic selective probing and all-optical electrophysiology to measure activity in an automated fashion. Here we demonstrate the ut...

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Bibliographic Details
Main Authors: Rebecca-Ann B. Burton, Jakub Tomek, Christina M. Ambrosi, Hege E. Larsen, Amy R. Sharkey, Rebecca A. Capel, Alexander D. Corbett, Samuel Bilton, Aleksandra Klimas, Guy Stephens, Maegan Cremer, Samuel J. Bose, Dan Li, Giuseppe Gallone, Neil Herring, Edward O. Mann, Abhinav Kumar, Holger Kramer, Emilia Entcheva, David J. Paterson, Gil Bub
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:iScience
Subjects:
Optical Imaging
Neuroscience
Techniques in Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305216

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http://www.sciencedirect.com/science/article/pii/S2589004220305216

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