Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses.

Expression of SigH, one of 12 Mycobacterium tuberculosis alternative sigma factors, is induced by heat, oxidative and nitric oxide stresses. SigH activation has been shown to increase expression of several genes, including genes involved in maintaining redox equilibrium and in protein degradation. H...

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Bibliographic Details
Main Authors: Jared D Sharp, Atul K Singh, Sang Tae Park, Anna Lyubetskaya, Matthew W Peterson, Antonio L C Gomes, Lakshmi-Prasad Potluri, Sahadevan Raman, James E Galagan, Robert N Husson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0152145