Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy

Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy

The tumor immune contexture plays a major role for the clinical outcome of patients. High densities of CD45RO+ T helper 1 cells and CD8+ T cells are associated with improved survival of patients with various cancer entities. In contrast, a higher frequency of tumor-infiltrating M2 macrophages is cor...

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Bibliographic Details
Main Authors: Ioana Plesca, Antje Tunger, Luise Müller, Rebekka Wehner, Xixi Lai, Marc-Oliver Grimm, Sergio Rutella, Michael Bachmann, Marc Schmitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
immune architecture
immune monitoring
immune checkpoint inhibition
cytotoxic T lymphocyte antigen 4
programmed cell death protein 1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00364/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00364/full

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