Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions

Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions

Chloramphenicol (CAM) is the D-threo isomer of a small molecule, consisting of a p-nitrobenzene ring connected to a dichloroacetyl tail through a 2-amino-1,3-propanediol moiety. CAM displays a broad-spectrum bacteriostatic activity by specifically inhibiting the bacterial protein synthesis. In certa...

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Bibliographic Details
Main Authors: George P. Dinos, Constantinos M. Athanassopoulos, Dionissia A. Missiri, Panagiota C. Giannopoulou, Ioannis A. Vlachogiannis, Georgios E. Papadopoulos, Dionissios Papaioannou, Dimitrios L. Kalpaxis
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Antibiotics
Subjects:
chloramphenicol
antibiotics
antibiotic resistance
side effects
anticancer agents
chemical synthesis
translation
ribosome
peptidyl transferase
puromycin reaction
Online Access:http://www.mdpi.com/2079-6382/5/2/20

Internet

http://www.mdpi.com/2079-6382/5/2/20

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