Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.

Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.

Directed evolution can be a powerful tool for revealing the mutational pathways that lead to more resistant bacterial strains. In this study, we focused on the bacterium Mycobacterium tuberculosis, which is resistant to members of the β-lactam class of antibiotics and thus continues to pose a major...

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Bibliographic Details
Main Authors: Christian Feiler, Adam C Fisher, Jason T Boock, Matthew J Marrichi, Lori Wright, Philipp A M Schmidpeter, Wulf Blankenfeldt, Martin Pavelka, Matthew P DeLisa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023821/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023821/?tool=EBI

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