BMS-599626, a Highly Selective Pan-HER Kinase Inhibitor, Antagonizes ABCG2-Mediated Drug Resistance

BMS-599626, a Highly Selective Pan-HER Kinase Inhibitor, Antagonizes ABCG2-Mediated Drug Resistance

Multidrug resistance (MDR) associated with the overexpression of ABC transporters is one of the key causes of chemotherapy failure. Various compounds blocking the function and/or downregulating the expression of these transporters have been developed over the last few decades. However, their potency...

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Bibliographic Details
Main Authors: Yunali V. Ashar, Jingchun Zhou, Pranav Gupta, Qiu-Xu Teng, Zi-Ning Lei, Sandra E. Reznik, Sabrina Lusvarghi, John Wurpel, Suresh V. Ambudkar, Zhe-Sheng Chen
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
BMS-599626
ABC transporters
ABCG2
multidrug resistance
chemotherapy
HER kinase inhibitor
Online Access:https://www.mdpi.com/2072-6694/12/9/2502

Internet

https://www.mdpi.com/2072-6694/12/9/2502

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