T-Cell Therapeutics Targeting Human Parainfluenza Virus 3 Are Broadly Epitope Specific and Are Cross Reactive With Human Parainfluenza Virus 1

T-Cell Therapeutics Targeting Human Parainfluenza Virus 3 Are Broadly Epitope Specific and Are Cross Reactive With Human Parainfluenza Virus 1

Human Parainfluenza Virus-3 (HPIV3) causes severe respiratory illness in immunocompromised patients and lacks approved anti-viral therapies. A phase I study of adoptively transferred virus-specific T-cells (VSTs) targeting HPIV3 following bone marrow transplantation is underway (NCT03180216). We sou...

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Bibliographic Details
Main Authors: Katherine M. Harris, Sarah E. Horn, Melanie L. Grant, Haili Lang, Gelina Sani, Mariah A. Jensen-Wachspress, Vaishnavi V. Kankate, Anushree Datar, Christopher A. Lazarski, Catherine M. Bollard, Michael D. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
parainfluenza
immunotherapy
T-cell
bone marrow transplant
anti-viral
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.575977/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.575977/full

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