The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid compound, potently activates Nrf2. This study aimed to investigate the protec...

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Bibliographic Details
Main Authors: Xiaobin Liu, Keith Ward, Christy Xavier, Jamieson Jann, Abbot F. Clark, Iok-Hou Pang, Hongli Wu
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Retinal pigment epithelial cells
Oxidative stress
RTA 408
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715300215

Internet

http://www.sciencedirect.com/science/article/pii/S2213231715300215

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