Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis.

Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis.

CC chemokine receptor 4 (CCR4) represents a potentially important target for cancer immunotherapy due to its expression on tumor infiltrating immune cells including regulatory T cells (Tregs) and on tumor cells in several cancer types and its role in metastasis.Using phage display, human antibody li...

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Bibliographic Details
Main Authors: Urs B Hagemann, Lavinia Gunnarsson, Solène Géraudie, Ulrike Scheffler, Remko A Griep, Herald Reiersen, Alexander R Duncan, Sergej M Kiprijanov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4117600?pdf=render

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http://europepmc.org/articles/PMC4117600?pdf=render

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