Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

Although Moracin D derived from Morus alba was known to have anti-inflammatory and antioxidant activities, the underlying antitumor mechanism of Moracin D has not been unveiled thus far. Thus, in the recent study, the apoptotic mechanism of Moracin D was elucidated in breast cancer cells. Herein, Mo...

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Bibliographic Details
Main Authors: Sung Min Hwang, Hyo-Jung Lee, Ji Hoon Jung, Deok Yong Sim, Jisung Hwang, Ji Eon Park, Bum Sang Shim, Sung-Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
Moracin D
apoptosis
FOXM1
β-catenin
GSK3β
Online Access:http://www.mdpi.com/1422-0067/19/9/2681

Internet

http://www.mdpi.com/1422-0067/19/9/2681

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