The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration.

The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration.

The Hippo-YAP pathway responds to diverse environmental cues to manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) and determine its physiological activity are still inconclusive. Here, we utilized an u...

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Bibliographic Details
Main Authors: Ruyuan Zhou, Qirou Wu, Mengqiu Wang, Seema Irani, Xiao Li, Qian Zhang, Fansen Meng, Shengduo Liu, Fei Zhang, Liming Wu, Xia Lin, Xiaojian Wang, Jian Zou, Hai Song, Jun Qin, Tingbo Liang, Xin-Hua Feng, Yan Jessie Zhang, Pinglong Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001122

Internet

https://doi.org/10.1371/journal.pbio.3001122

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