Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation

Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation

Liver fibrosis is mediated by myofibroblasts, a specialized cell type involved in wound healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major source of myofibroblasts in the fibrotic livers. In the present study we investigated the involvement of CXXC-type zinc-fing...

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Bibliographic Details
Main Authors: Xiaoyan Wu, Wenhui Dong, Ming Kong, Haozhen Ren, Jinglin Wang, Longcheng Shang, Zhengyi Zhu, Wei Zhu, Xiaolei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transcriptional regulation
epigenetics
transcription repressor
liver fibrosis
hepatic stellate cells
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.680344/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.680344/full

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