CHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1

CHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1

Abstract Transcriptional factor nuclear factor κB (NF-κB) can be activated by various intracellular or extracellular stimuli and its dysregulation leads to pathological conditions, such as neurodegenerative disorders, infection, and cancer. The carboxyl terminus of HSC70-interacting protein (CHIP),...

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Bibliographic Details
Main Authors: Yuchun Liu, Yao Sun, Shaoming Han, Yanan Guo, Qingnan Tian, Qiang Ma, Shoutao Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00637-3

Internet

https://doi.org/10.1038/s41420-021-00637-3

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