Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation

Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation

Summary: Plasma cells provide high-affinity antibodies against invading pathogens. Although transcriptional and epigenetic mechanisms have been extensively studied for plasma cell differentiation, how these mechanisms respond to environmental cues remains largely unexplored. In this study, we show t...

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Bibliographic Details
Main Authors: Tuan Qi, Mengmeng Sun, Chao Zhang, Pengda Chen, Changchun Xiao, Xing Chang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
Ascorbic acid
Ten-eleven translocation (TET) enzymes
Germinal center B cell
Plasma B cell
Blimp-1
Immune respones
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314418

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http://www.sciencedirect.com/science/article/pii/S2211124720314418

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