Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways.

Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways.

The obligate intracellular parasite, Toxoplasma gondii, disseminates through its host inside infected immune cells. We hypothesize that parasite nutrient requirements lead to manipulation of migratory properties of the immune cell. We demonstrate that 1) T. gondii relies on glutamine for optimal inf...

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Bibliographic Details
Main Authors: I-Ping Lee, Andrew K Evans, Cissy Yang, Melissa G Works, Vineet Kumar, Zurine De Miguel, Nathan C Manley, Robert M Sapolsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4192591?pdf=render

Internet

http://europepmc.org/articles/PMC4192591?pdf=render

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