Small molecule-mediated refolding and activation of myosin motor function

Small molecule-mediated refolding and activation of myosin motor function

The small molecule EMD 57033 has been shown to stimulate the actomyosin ATPase activity and contractility of myofilaments. Here, we show that EMD 57033 binds to an allosteric pocket in the myosin motor domain. EMD 57033-binding protects myosin against heat stress and thermal denaturation. In the pre...

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Bibliographic Details
Main Authors: Michael B Radke, Manuel H Taft, Britta Stapel, Denise Hilfiker-Kleiner, Matthias Preller, Dietmar J Manstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
myosin
protein folding
allostery
pharmacological chaperone
Online Access:https://elifesciences.org/articles/01603

Internet

https://elifesciences.org/articles/01603

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