Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability.

Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability.

Autologous transplantation of spermatogonial stem cells is a promising new avenue to restore fertility in infertile recipients. Expansion of the initial spermatogonial stem cell pool through cell culturing is a necessary step to obtain enough cells for effective repopulation of the testis after tran...

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Bibliographic Details
Main Authors: Robert B Struijk, Lambert C J Dorssers, Peter Henneman, Martin A Rijlaarsdam, Andrea Venema, Aldo Jongejan, Marcel M A M Mannens, Leendert H J Looijenga, Sjoerd Repping, Ans M M van Pelt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0230253

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https://doi.org/10.1371/journal.pone.0230253

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