Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Abstract Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia. The highlighted mechanism involves a metabolic switch from oxidative phosphorylation toward glycolysi...

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Main Authors: Marc Cougnon, Romain Carcy, Nicolas Melis, Isabelle Rubera, Christophe Duranton, Karine Dumas, Jean-François Tanti, Catherine Pons, Nicolas Soubeiran, Marina Shkreli, Thierry Hauet, Luc Pellerin, Sébastien Giraud, Nicolas Blondeau, Michel Tauc, Didier F. Pisani
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03577-z

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https://doi.org/10.1038/s41419-021-03577-z

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