Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis

Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis

Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H+ ions reducing the intracellular pH (pHi). Nevertheless, how extracellular pH reg...

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Bibliographic Details
Main Authors: Meraj A. Khan, Lijy M. Philip, Guillaume Cheung, Shawn Vadakepeedika, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Medicine
Subjects:
neutrophil extracellular trap formation
pH
spontaneous NETosis
NADPH-dependent NETosis
lipopolysaccharide-induced NETosis
Gram-negative bacteria-induced NETosis
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00019/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2018.00019/full

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