The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling

The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling

Hypothesis/Introduction: The pathophysiological role of oxidative stress (OxSt) in hypertension and target organ damage is recognized. Angiotensin II (Ang II) induces OxSt via NAD(P)H oxidase activation and production of proinflammatory cytokines/growth factors leading to cardiovascular-renal remode...

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Bibliographic Details
Main Authors: Verdiana Ravarotto, Elisa Pagnin, Giuseppe Maiolino, Antonio Fragasso, Gianni Carraro, Barbara Rossi, Lorenzo A Calò
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2015-12-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320315594324

Internet

https://doi.org/10.1177/1470320315594324

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