The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling
Hypothesis/Introduction: The pathophysiological role of oxidative stress (OxSt) in hypertension and target organ damage is recognized. Angiotensin II (Ang II) induces OxSt via NAD(P)H oxidase activation and production of proinflammatory cytokines/growth factors leading to cardiovascular-renal remode...
Main Authors: | Verdiana Ravarotto, Elisa Pagnin, Giuseppe Maiolino, Antonio Fragasso, Gianni Carraro, Barbara Rossi, Lorenzo A Calò |
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Format: | Article |
Language: | English |
Published: |
Hindawi - SAGE Publishing
2015-12-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320315594324 |
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