Heterogeneous Nuclear Ribonucleoprotein E2 (hnRNP E2) Is a Component of TDP-43 Aggregates Specifically in the A and C Pathological Subtypes of Frontotemporal Lobar Degeneration

TAR DNA-binding protein 43 (TDP-43) is the major component of the ubiquitin-positive protein aggregates seen in the majority of frontotemporal lobar degeneration and amyotrophic lateral sclerosis cases. TDP-43 belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family that is involved in...

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Bibliographic Details
Main Authors: Wejdan Kattuah, Boris Rogelj, Andrew King, Christopher E. Shaw, Tibor Hortobágyi, Claire Troakes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
ALS
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00551/full