EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb repress...

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Bibliographic Details
Main Authors: Sung-Hak Kim, Kaushal Joshi, Ravesanker Ezhilarasan, Toshia R. Myers, Jason Siu, Chunyu Gu, Mariko Nakano-Okuno, David Taylor, Mutsuko Minata, Erik P. Sulman, Jeongwu Lee, Krishna P.L. Bhat, Anna Elisabetta Salcini, Ichiro Nakano
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111400383X

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http://www.sciencedirect.com/science/article/pii/S221367111400383X

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