Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity

Manipulating the NKG2D Receptor-Ligand Axis Using CRISPR: Novel Technologies for Improved Host Immunity

The activating immune receptor natural killer group member D (NKG2D) and its cognate ligands represent a fundamental surveillance system of cellular distress, damage or transformation. Signaling through the NKG2D receptor-ligand axis is critical for early detection of viral infection or oncogenic tr...

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Bibliographic Details
Main Authors: Eric Alves, Emily McLeish, Pilar Blancafort, Jerome D. Coudert, Silvana Gaudieri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
NKG2D
CRISPR
precision medicine
NK cells
viral infection
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712722/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.712722/full

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